Tissue Engineering of Tubular and Solid Organs: An Industry Perspective

نویسندگان

  • Joydeep Basu
  • John W. Ludlow
چکیده

Tissue engineering and regenerative medicine (TE/RM) represents a broad spectrum of cell and biomaterial based approaches aiming to repair, augment and regenerate diseased tissues and organs. The successful recent clinical implantation of tissue engineered trachea, bladder and bladder derivative (Neo-Urinary ConduitTM) has highlighted the emergence of common methodological frameworks for the development of TE/RM approaches that may be broadly applicable towards the regeneration of multiple, disparate tubular organs. Similarly, recent progress towards regeneration of heart, kidney, liver, pancreas, spleen and central nervous system is identifying shared methodologies that may underlie the development of foundational platform technologies broadly applicable towards the regeneration of multiple solid organ systems. Central themes emerging for both tubular and solid neo-organs include the application of a biodegradable scaffold to provide structural support for developing neo-organs and the role of committed or progenitor cell populations in establishing the regenerative micro-environment of key secreted growth factors and extra-cellular matrix critical for catalyzing de novo organogenesis. However, aspects of these strategies currently under active development for tissue engineering of tubular and solid neo-organs may not be relevant for successful commercialization of neo-organs as novel TE/RM products for clinical application. For example, difficulties in large scale sourcing and quality control of biomaterials derived from decellularization of cadaveric organs imply that such biomaterials may be less suitable for incorporation into TE/RM products when compared to biomaterials of synthetic origin. Similarly, TE/RM technologies that attempt to leverage populations of stem and progenitor cells are less likely than platforms focused on committed cell populations or acellular biomaterials to facilitate rapid development of viable products. In this chapter, we will present our experience in the development of the Neo-Bladder AugmentTM, Neo-Urinary ConduitTM and Neo-Kidney AugmentTM to identify elements of this foundational organ regeneration technology platform that may be broadly applicable towards the design and development of additional tubular neo-organ products, including the esophagus and small intestine, the lung, the vasculature and the male or female genitourinary tract as well as additional solid neo-organs. We will focus specifically on highlighting aspects of these neo-organ regenerative platforms conducive to the commercial viability of such technologies.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Dynamic Response Analysis of the Planar and Tubular Solid Oxide Fuel Cells to the Inlet Air Mass Flow Rate Variation

The purpose of present study is to investigate the dynamic response of two conventional types of solid oxide fuel cells to the inlet air mass flow rate variation. A dynamic compartmental model based on CFD principles is developed for two typical planar and tubular SOFC designs. The model accounts for transport processes (heat and mass transfer), diffusion processes, electrochemical processes, a...

متن کامل

Solid organ fabrication: comparison of decellularization to 3D bioprinting

Solid organ fabrication is an ultimate goal of Regenerative Medicine. Since the introduction of Tissue Engineering in 1993, functional biomaterials, stem cells, tunable microenvironments, and high-resolution imaging technologies have significantly advanced efforts to regenerate in vitro culture or tissue platforms. Relatively simple flat or tubular organs are already in (pre)clinical trials and...

متن کامل

Engineering complex tissues.

Tissue engineering has emerged at the intersection of numerous disciplines to meet a global clinical need for technologies to promote the regeneration of functional living tissues and organs. The complexity of many tissues and organs, coupled with confounding factors that may be associated with the injury or disease underlying the need for repair, is a challenge to traditional engineering appro...

متن کامل

Tubular organ epithelialisation

Hollow, tubular organs including oesophagus, trachea, stomach, intestine, bladder and urethra may require repair or replacement due to disease. Current treatment is considered an unmet clinical need, and tissue engineering strategies aim to overcome these by fabricating synthetic constructs as tissue replacements. Smart, functionalised synthetic materials can act as a scaffold base of an organ ...

متن کامل

Revolutionizing Tissue Engineering through Mirroring Cell Niche and Application of Natural Compounds

onsidering the high prevalence of severe organ failures due to the cancer, congenital anomaly, or trauma, and the consequent needs for tissue transplantation, deficiencies in tissues and organs are a huge challenge for regenerative medicine at the moment. More than 40 years have passed since the term ‘tissue engineering’ was created as a new th...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2012